Ageing, age-related diseases and oxidative stress: What to do next?

Oxidative Stress and Epigenetic Regulation in Ageing and Age-Related Diseases

Recent statistics indicate that the human population is ageing rapidly. Healthy, but also diseased, elderly people are increasing. This trend is particularly evident in Western countries, where healthier living conditions and better cures are available. To understand the process leading to age-associated alterations is, therefore, of the highest relevance for the development of new treatments f...

Oxidative Stress in Neurodegenerative Diseases and Ageing

Since Denham Harman has proposed the free radical theory of ageing, the knowledge and the understanding of the mechanisms of ageing process have increased remarkably. Over decades, this unavoidable phenomenon has also been linked, both causatively and consequently, with the development of several abnormalities, currently known as the “agerelated diseases.” Oxidative Medicine and Cellular Longev...

where do we stand and what comes next?

Autophagy and ageing: implications for age-related neurodegenerative diseases.

Autophagy is a process of lysosome-dependent intracellular degradation that participates in the liberation of resources including amino acids and energy to maintain homoeostasis. Autophagy is particularly important in stress conditions such as nutrient starvation and any perturbation in the ability of the cell to activate or regulate autophagy can lead to cellular dysfunction and disease. An ar...

Ageing, smoking and oxidative stress.

C hronic obstructive pulmonary disease (COPD) is the fifth leading cause of death worldwide and further increases in its prevalence and mortality are expected in the coming decades. Continued exposure to tobacco promotes a more rapid decline in lung function and, if exposure is stopped, the disease may still progress due to ageing and persistence of inflammation. The paper by Nagai et al in thi...